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What are peptides in skincare? A beginner's guide

Peptides are everywhere in skincare right now. Here's what they are, the main types and how to pick a good peptide serum.

5 min read · Updated September 27, 2026
Key takeaways
  • Peptides are short chains of amino acids.
  • Main types: signal peptides, carrier peptides (like GHK-Cu) and expression-line peptides.
  • Good peptide serums combine several types and disclose key concentrations.

Peptides in one line

Amino acids are building blocks; link a few together and you get a peptide. Link many and you get a protein, like collagen or elastin.

The main types

TypeExampleUsed for
Carrier peptidesGHK-Cu (copper peptide)Delivering copper; renewal and firmness
Signal peptidesPalmitoyl tripeptide-5Supporting the look of firmness
Expression-line peptidesAcetyl hexapeptide-8Softening the look of movement lines
Calming peptidesPalmitoyl tetrapeptide-7Calming the look of redness

How to choose a peptide serum

See how DOSE combines seven: the 7 peptides in DOSE.

  • Look for multiple peptides. One peptide covers one concern.
  • Check for disclosed concentrations, like DOSE's 2% GHK-Cu.
  • Go fragrance-free if your skin is sensitive.
  • Commit to 6–8 weeks. Peptides reward consistency.

FAQ

Do peptides actually work?

Peptides are among the best-studied cosmetic ingredients. Results build gradually over several weeks of consistent use and vary by person.

Are peptides better than retinol?

They're different: peptides are gentler and can be used twice a day, while retinol is stronger but more irritating. Many people use both.

Can I use peptides every day?

Yes, most peptide serums are designed for twice-daily use.

This article is for general information only and isn't medical advice. DOSE is a cosmetic product and is not intended to diagnose, treat, cure or prevent any disease. Individual results vary.