- GHK-Cu is a small peptide (three amino acids) bound to a copper ion.
- It occurs naturally in the body, and levels are generally reported to fall as we age.
- In skincare it's used to support the look of firmer, smoother, more even skin and a healthy-looking skin barrier.
- It works best used consistently, twice a day, for at least 6–8 weeks.
GHK-Cu in one sentence
GHK-Cu is a tiny peptide made of three amino acids (glycine, histidine and lysine) carrying a copper ion, which is why you'll see it called a copper peptide or copper tripeptide-1 on ingredient lists.
Where it comes from
GHK was first identified in human plasma in the early 1970s by researcher Loren Pickart, who noticed it had a strong affinity for copper. Since then it has become one of the most studied peptides in skincare research.
Your body makes GHK naturally. Levels are commonly reported to be higher when we're young and lower later in life, which is one reason it became interesting to skincare formulators.
What GHK-Cu does for the look of your skin
In cosmetic formulas, GHK-Cu is used because it supports several things at once, which is rare for a single ingredient:
- Firmness: it's associated with supporting the skin's collagen and elastin, which help skin look firm and bouncy.
- Smoothness: with consistent use, skin texture and the look of fine lines can appear softer.
- Barrier support: it helps skin look and feel more resilient and comfortable.
- Renewal: skin can look fresher and more even over time.
Why 2%?
Many copper peptide products don't disclose their concentration, or use a very small amount. DOSE uses 2% GHK-Cu, a meaningful level that's still comfortable for daily use, then pairs it with six supporting peptides so one step covers firmness, smoothness and hydration. See the 7 peptides in DOSE.
Why copper peptide serums are blue
Copper gives GHK-Cu a natural blue colour, so a genuine copper peptide serum is usually a clear blue liquid. The colour comes from the copper itself, not a dye. DOSE contains no added fragrance or colourants.
How to use a GHK-Cu serum
- CleanseStart with clean, dry skin.
- ApplyPress 3–4 drops into your face, morning and night.
- FinishMoisturise if you like, and always wear SPF in the morning.
Keep strong acids and vitamin C for a different time of day. Here's the full copper peptide routine.
Who it's for
GHK-Cu suits most skin types, including dry, combination and oily skin. If your skin is reactive, start once a day and read copper peptides for sensitive skin first.
FAQ
Is GHK-Cu the same as copper peptides?
GHK-Cu is the best-known copper peptide, and when people say "copper peptides" they usually mean GHK-Cu (also listed as copper tripeptide-1).
How long does GHK-Cu take to work?
Skin often feels more hydrated right away. Visible changes in texture, fine lines and firmness usually take 6–8 weeks of twice-daily use. Individual results vary.
Can I use GHK-Cu every day?
Yes. It's designed for twice-daily use. If your skin is sensitive, start once a day and build up.
This article is for general information only and isn't medical advice. DOSE is a cosmetic product and is not intended to diagnose, treat, cure or prevent any disease. Individual results vary.